Importantly, immunohistochemical analysis showed that Yap is accumulated predominantly in inter-cardiomyocyte areas (Figure 1E, left panel), where cells positive for fibroblast-specific vimentin (Figure 1E, right panel) are mainly located, strongly suggesting cardiac fibroblasts as a cell type of Yap accumulation in LV of patients with HF. Here, VIM is linked to hydrops fetalis.