TGFB1 and hydrops fetalis: Given the concomitant increase in Yap and collagen I levels under combined treatment, we investigated the potential role for Yap as an upstream promoter of fibroblast collagen accumulation under the HF-related stimuli TGFβ/hypoxia by depleting Yap in human cardiac fibroblasts using adenoviral delivery of shRNA (Supplementary Figure S1B) [7].