The TME is a dynamic network of interactions between cancer cells, stromal tissue and the surrounding ECM involving fibrous proteins such as elastin, collagens, fibronectin, and laminins, as well as cellular proteases, such as cathepsins, matrix metalloproteinases, and heparinase, and proteins associated with intercellular interactions, integrins, and laminins [16]. Here, FN1 is linked to cancer.