IBSP and breast cancer: These proteins include tenascin-N (TNN), overexpressed in most mammary tumors and associated with migration [74]; integrin-binding sialoprotein (IBSP), which protects cells from complement-mediated cellular lysis [75]; and transforming growth factor-beta (TGF-b 2 and 3), which plays an important role in mediating fibrotic tissue remodeling [76].