Considering that the deregulation of TLRs and NLRP3 is closely related to the severity of SARS-CoV-2 pathology, it can be assumed that glycosyl flavonoids could exert significant antiviral and immunomodulatory effects mediated through TLRs or NLRP3 inflammasomes in COVID-19 patients. This evidence concerns the gene NLRP3 and COVID-19.