On the other hand, other results indicate that the absence of FGFR4 accelerates the progression of chemical-induced HCC, and hence FGFR4 has an important anti-proliferative effect [31,34], and the down-regulation of FGFR4 is related to a higher risk of hepatotumorigenesis [32]. The gene discussed is FGFR4; the disease is hepatocellular carcinoma.