AGR2 and cancer: The cancer associated functions of AGR2 have been inferred from several lines of research including (i) AGR2 drives cement gland production, whose function promotes the attachment of the growing epithelium to a solid support [6], (ii) AGR2 can mediate metastatic growth in cancer models [7], and (iii) AGR2 can mediate limb regeneration in amphibia [8].