TLR4 and Multiple Organ Failure: It has been suggested that overexpression of pro-inflammatory cytokines happens because the SARS-CoV-2 spike protein interacts strongly with TLR-4, causing an intensely exacerbated immune response in the host’s lungs, culminating with the cytokine storm, accumulating secretions and hindering blood oxygenation, along with the immune system attacks the body, leading to multiple organ failure [48].