We examined the effect of catechins on autophagy, apoptosis and PI3K/AKT/m-TOR signaling in LPS-induced ALI by evaluating the protein levels of Beclin-1/Atg5-Atg12/LC3-II, caspase 3/PARP and phosphorylated PIK3/AKT/m-TOR with Western blotting. This evidence concerns the gene ATG12 and acute respiratory distress syndrome.