In this study, we aimed to evaluate potential anti-inflammatory and antiviral catechins, as a new strategy for directly inhibiting SARS-CoV replication, promoting CD25/CD69/CD94 expression on CD8+ cytotoxic T cells to enhance adaptive immunity and attenuating LPS evoked ALI and cytokine storm through PI3K/AKT/mTOR mediated Beclin-1/Atg5-Atg12/LC3-II related autophagy in mice. Here, ATG12 is linked to acute respiratory distress syndrome.