Furthermore, because miRNA-101 plays a crucial role in TGF-β modulation [41,44], we assume that the upregulation of MALAT1 leads to the subsequent downregulation of miRNA-101, promoting the expression of TGF-β, leading to eventually diminishing E-cadherin, promoting metastasis and CRC progression. This evidence concerns the gene MALAT1 and colorectal carcinoma.