PVT1 and colorectal carcinoma: Furthermore, serum PVT1 expression was upregulated significantly in CRC and AP patients compared to healthy controls, with a median (IQR) fold change of 117.6 (29.96–279.8) (p < 0.0001) and 23.03 (6.75–49.29) (p = 0.0148), respectively.