Denoting to E-cadherin, ROC analysis revealed that it could discriminate CRC from healthy controls with an AUC = 0.892, 95% CI = 0.8189 to 0.9646, p < 0.0001, with sensitivity of 70%, and specificity of 95% at a cutoff < 3.661 ng/mL (Figure 4I). The gene discussed is CDH1; the disease is colorectal carcinoma.