Regarding lncRNAs, ROC analysis revealed that serum MALAT1 and PVT1 distinguished patients with CRC from healthy controls with an AUC = 0.965, 95% CI = 0.9261 to 0.991, p < 0.0001, with sensitivity of 89%, specificity of 95% at a cutoff > 10.70-fold and an AUC = 0.915, 95% CI = 0.8441 to 0.9859, p < 0.0001, with sensitivity of 90%, specificity of 95% at a cutoff > 13.96-fold, respectively. This evidence concerns the gene MALAT1 and colorectal carcinoma.