TGFB1 and pulmonary fibrosis: Furthermore, inhibition of Hsp90 by 17-N-allylamino-17-demethoxy-geldanamycin (17-AAG) efficiently reduced TGF-β-driven activation of fibroblasts and production of ECM in vitro and attenuated progression of established fibrosis in a mouse model of pulmonary fibrosis [51].