However, the potential impact of 17-DMAG in the preclinical models of SSc on serum levels of other cytokines and chemokines, which play vital roles in the pathogenesis of SSc and the progression of fibrosis, such as TGF-β [3] and IL-8 [71], needs to be elucidated by further investigation. This evidence concerns the gene CXCL8 and systemic sclerosis.