Nedd4-2 was also shown to play a role in the posttranslational regulation of SP-C expressed in AT2 cells, and previous studies found mutations in the SFTPC gene in association with the development of ILD both in children (chILD) and in familial IPF in adults [21,22,23,24,25,26]. The gene discussed is NEDD4L; the disease is interstitial lung disease.