NEDD4L and interstitial lung disease: First, the onset and progression of ILD was substantially accelerated in congenital vs. conditional Nedd4-2−/− mice, as evidenced by the time point of mortality that occurred within ~4 weeks after birth in most neonatal congenital Nedd4-2−/− mice compared to ~4 months after conditional deletion of Nedd4-2−/− in adult mice (Figure 1) [9].