CASP3 and neoplasm: The O-acetylated derivative of GD2, OAcGD2, is not expressed on peripheral nerves, and mAb 8B6 could inhibit the growth of OAcGD2-positive tumor cell lines in vitro and could also suppress tumor growth in mice by reducing the proliferation index and inducing the caspase 3-dependent mitochondrial apoptotic pathway [93].