On this basis, the INFINITY study was designed, aimed at assessing the activity and safety of the combination of the anti-CTLA4 tremelimumab and the anti-PD-L1 durvalumab as a neoadjuvant or potentially definitive treatment for MSI-H, dMMR and EBV negative, early-stage and resectable GC/GEJC. The gene discussed is CTLA4; the disease is gastric cancer.