However, the chronic stimulation of iNOS by the metabolic syndrome milieu leads to markedly increased levels of NO and O2− which react to form ONOO−, a potent prooxidant, which along with O2− and H2O2, uncouples the iNOS dimer to alter its functional activity to inappropriately generate even higher levels of O2− [41,42,43,44,45,46,47]. Here, NOS2 is linked to metabolic syndrome.