Previous notable studies by M.A. Bentsen et al. [101] have demonstrated that the long-term anti-diabetic effect of fibroblast growth factor 1 (FGF 1) involves the short-term (1–5 day) induction followed by the longer term (14–42 day) attenuation of these genes in the MBH area of treated diabetes mice. Here, FGF1 is linked to diabetes mellitus.