TRPV1 and granular corneal dystrophy type II: In the squaric acid dibutylester (SADBE)-induced ACD model, SADBE not only directly activates the TRPV1 channel but also TRPV1 was expressed on MrgprA3 and MrgprD expressing DRG neurons, and the authors concluded that these TRPV1+ neurons were responsible for the persistent itch signal after SADBE exposure [92].