EGFR and papilloma: However, a recent examination of this antagonist and two other TRPV1 antagonists (SB-705498 and PAC-14028) in normal human epidermal keratinocytes (NHEK) and HaCat cells found no change in cell proliferation or EGFR/Akt/mTOR signaling pathway protein expression, nor could AMG-9810-treated skins activate the EGFR signaling pathway in TPA-induced papilloma formation [67].