Mice deficient in TRPV1 with the cecal ligation and puncture (CLP) model of sepsis suffered from more severe disease compared to WT mice, including increased peritoneal mononuclear cell apoptosis, decreased neuropeptide-dependent phagocytosis, decreased reactive oxygen species, increased inflammatory mediator levels, and reduced bacterial clearance [69]. Here, TRPV1 is linked to Sepsis.