For instance, granulovacuolar degeneration bodies (GVBs)—a poorly understood vacuolar structure often found to accumulate in the brain of tauopathy patients—were formed in neurons in both WT and P301L Tg mice following injection of recombinant P301L tau and human brain extracts from AD, PSP, and PART patients [141]. This evidence concerns the gene MAPT and Alzheimer disease.