IGF2R and preeclampsia: Four animal studies have reported that BPA exposure can provoke intrauterine growth restriction [44], cause preeclampsia-like features in pregnant mice involved in the reprogramming of DNA methylation of WNT2 (Wnt family member-2) [45], and cause toxicity in spermatocytes, and DNA methylation may exert an important role in BPA-triggered male reproductive toxicity [46] and alter the methylation levels of differentially methylated regions (DMRs) including the Snrpn imprinting control region and IGF2R DMR1 [47].