Glioma angiogenesis is controlled and regulated by a broad spectrum of proangiogenic factors, which include members of VEGF family, FGF family, angiopoietins and angiopoietin-like proteins, cytokines from the TGF-β family, various enzymes from the MMPs family as well as proangiogenic CXC ELR (+) and CC chemokines and their receptors. This evidence concerns the gene TGFB1 and central nervous system cancer.