As shown in Figure 2, the expression of NK-3R was observed not only in the tumor cells (Figure 2A Tm and Figure 2B), but also in the almost osteoclasts (Figure 2A OC and Figure 2B), which were correlated with the expression of CD68-positive cells (Figure 2C,E, arrowheads) at the tumor bone invasion front. This evidence concerns the gene CD68 and neoplasm.