TP53 and B-cell chronic lymphocytic leukemia: Examples include the CLL-IPI, IPS-E, CLL1 prognostic model (CLL1-PM), BALL score, four-factor prognostic model, SRSI and others, which use covariates such as age, stage, hemoglobin concentration, lactate dehydrogenase, beta-2 microglobulin and mutation states of IGHV and TP53 to predict outcomes [29,30,31,32,33,34,35].