Vitamin D deficiency in association with the RUNX2 gene mutation, that is involved in bone remodeling, tooth formation and eruption, might be the cause of multiple dental inclusions [78] in patients with cleido-cranial-dysplasia in which skeletal anomalies, short stature, osteopenia, and osteoporosis are also present [79]. The gene discussed is RUNX2; the disease is osteoporosis.