M2 (alternatively activated) macrophages express the CD163 antigen and are thought to be modulated by IL-4 and -13 and associated with tumor formation [22], secreting VEGF and TGFβ to promote angiogenesis [15,23] and establishing a pro-fibrogenic and anti-inflammatory phenotype along with connective tissue remodeling [24]. This evidence concerns the gene CD163 and neoplasm.