Risk factors for severe infection include obesity (body mass index [BMI] ≥ 28 kg/m2), type 2 diabetes, hypertension, elevated lactate dehydrogenase (LDH > 250 U/L), C-reactive protein (CRP > 10 mg/L), and albumin (ALB < 35 g/L) [16]. The gene discussed is ALB; the disease is obesity due to melanocortin 4 receptor deficiency.