LPAR1 and Familial prostate cancer: In detail, the cancer cell lines expressing moderate to high levels of LPA1, such as MDA-MB-231 (breast cancer), PC-3 (prostate cancer), A-2058 (melanoma), A549 (lung cancer), ACHN (renal cancer) and SF295 (glioblastoma), exhibited enhanced migration in response to LPA; however, LPA did not support the migration of MCF7 (breast cancer), KM-12 (colorectal cancer) and OVCAR-4 (ovarian cancer), which express LPA2 but not LPA1, or the migration of LNCaP (prostate cancer), which expresses LPA3 but not LPA1 [39].