LPAR1 and breast carcinoma: In the breast cancer model induced in immune-competent Balb/c mice through intramammary injection of murine 4T1 mammary carcinoma cells, tumor capability to metastasize early was mediated mainly by LPA1, and the administration of a highly specific LPA1 antagonist, Debio-0719, reduced the number of spontaneously disseminated tumor cells to bones and the lungs [61].