CAFs—apart from being crucial for the synthesis of collagens, fibronectin and other TME structural components [95]—support tumor invasion and dissemination (e.g., by releasing MMP-2 and MMP-9), help cancer cell proliferation (e.g., through the release of SDF-1, FGF and osteopontin [96,97]) and promote angiogenesis (e.g., through the expression of adrenomedullin and VEGF [84,98]). The gene discussed is CXCL12; the disease is cancer.