MOG and encephalomyelitis: This hypothesis was confirmed by our data, which we obtained by immunizing control monocyte-derived M1-Mφ and M2-Mφ with the highly encephalitogenic peptide myelin oligodendrocyte glycoprotein (MOG35-55), by which M1 and M2 phenotypes partially mimicked those obtained from EAE-induced macrophages, possibly indicating that the changes in macrophage function could play an important role in the pathogenic mechanisms triggered by this peptide upon the induction of encephalomyelitis.