IN_in_r1 induces a preferable profile of immune response rich in IFN-γ/TNF-α/IL-2 and IFN-γ/IL-2/GrB producing CD8+ T cells, and IFN-γ/TNF-α and IFN-γ/IL-2/TNF-α producing CD4+ T cells, allowing better control of tumor cell challenge. Here, GZMB is linked to neoplasm.