AVP and Cushing syndrome due to macronodular adrenal hyperplasia: Paraneoplastic syndromes were described about 100 years ago and, over the time, many forms of endocrinological interest have been identified that can cause CS, Cushing’s syndrome, syndrome of inappropriate ADH secretion, hypoglycemia, hypercalcemia, and acromegaly, depending on the substances produced by the neoplasm.