Neuronal activity promotes glioma proliferation through the release of the soluble factor neuroligin-3 (NLGN3) [198,199], and peritumoral neurons directly interact with glioma cells through AMPA-mediated synapses that drive tumor growth and invasion [200,201], opening new stimulating perspectives to the understanding of the complex glioma-brain parenchyma interactions. The gene discussed is NLGN3; the disease is central nervous system cancer.