Paradoxically, though Bcl-2 expression is associated with longer survival in breast cancer [59,62] and unlike XIAP that suppresses both death receptor/extrinsic and mitochondrial apoptosis, Bcl-2 can only inhibit intrinsic/mitochondrial-mediated apoptosis, suggesting that targeting XIAP may be more relevant to treatment of breast cancer. The gene discussed is XIAP; the disease is breast cancer.