A signaling pathway such as this one, which is involved in both development and brain plasticity, is an excellent target for the study of neurodevelopmental disorders, hence the increasing number of studies addressing the implications of intrauterine partial nutrient deficiencies, inflammation, or maternal infection, which modify the expression of the reelin gene [21,22] and may be the basis for schizophrenia, autism, or bipolar disorder, among other diseases [23]. Here, RELN is linked to bipolar disorder.