Notably, levels of fuco-SERPINA1 were also significantly higher in PC patients with distant metastasis (M1) than the metastasis-free (M0) PC group (M0: 228.6 ng/mL; M1: 361.1 ng/mL, p = 0.043) (Figure 6b). This evidence concerns the gene SERPINA1 and pachyonychia congenita.