SERPINA1 and pachyonychia congenita: Taken together, these results confirmed our findings from the quantitative glycoproteomics study, demonstrating that (i) both plasma SERPINA1 and fuco-SERPINA1 levels are significantly elevated in PC compared to GS patients, and (ii) the observed increase in plasma fuco-SERPINA1 levels is mainly due to significant elevation in cases of PC with distant metastasis.