In a recent study, authors suggest that TTR, which is elevated in insulin-resistant ob/ob (obese) mice [22] and in some insulin-resistant humans [31], is a key determinant by regulating the levels of RBP4, since RBP4 binding to TTR reduces the glomerular filtration rate of RBP4 and retains it in the blood [32]; Elevated levels of RBP4 cause insulin resistance and impair insulin signaling in mice. The gene discussed is RBP4; the disease is Insulin resistance.