TTR and diabetes mellitus: As studies show that glucose can stimulate transcription of the PKM gene [35] and that hyperglycemia and diabetes decrease PKM activity in mouse glomeruli [36], it suggests that PKM activation increases glucose metabolic flux, and that our observation of decreased PKM expression in TTR+/− livers could suggest a decreased utilization of glucose for glycolysis, leading to less ATP being produced in this step of glycolysis.