More importantly, mutations in the NLRP3 gene (coding for cryopyrin) are associated with a group of clinically distinct disorders known as cryopyrin-associated periodic syndromes (CAPS) and encompass a spectrum of phenotypes described as familial cold autoinflammatory syndrome, Muckle–Wells syndrome and neonatal-onset multisystem inflammatory disease. Here, NLRP3 is linked to cryopyrin-associated periodic syndrome.