In fact, members of the NLR family, including NLRP3, PYRIN and PYHIN family proteins (recognition receptors such as absent in melanoma 2 (AIM2), recently reported to play roles in cell cycle, tumor suppression and transcriptional regulation), have all been shown to assemble inflammasomes in response to cytosolic pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) [9,26,27]. Here, AIM2 is linked to neoplasm.