The local folding structure of RNA was altered when the T allele on rs10132552 was replaced by the C allele, which then affected the function of MEG3. Likewise, the results of the study by Bayarmaa et al. proved that MEG3 rs10132552 was also related to chemotherapy response in breast cancer patients treated with paclitaxel or cisplatin [23]. The gene discussed is MEG3; the disease is breast cancer.