In this study, we estimated the contribution of SLC6A4 (5HTT), HTR1A, HTR2A, HTR1B, SLC6A3 (DAT1), DRD4, DRD2, COMT, and BDNF genes to the suicidal behavior and severity of symptoms of depression and anxiety in the East-Slavic population of Russia. This evidence concerns the gene HTR2A and major depressive disorder.