Lirilumab (IPH2101), a novel anti-inhibitory KIR antibody designed to prevent NK cell recognition of MHC-I inhibitory signals, was investigated in a phase 2 clinical trial (NCT01687387) for adult acute myeloid leukemia (AML) where it failed to show statistical improvement of leukemia free survival [25]. The gene discussed is KIR3DL1; the disease is acute myeloid leukemia.