It was proposed that CSCs from CRC secrete ET-1 and that the activation of the ETRA receptor/β-arrestin1 axis induces the cross-talk with β-catenin signaling to sustain stemness, the epithelial-to-mesenchymal transition (EMT) phenotype, and regulates the response to chemotherapy [29]. Here, EDN1 is linked to colorectal carcinoma.