In the cohort of CRC patients, HO-1 and ECE-1 expressions positively correlated in all cases (Rp = 0.723, p < 0.001; Figure 4e) in tumors harboring a wild-type p53 (Rp = 0.699, p < 0.001; Figure 4f) and in tumors with mutations in this gene (Rp = 0.755, p < 0.001; Figure 4g). This evidence concerns the gene ECE1 and colorectal carcinoma.