TNF and coronary artery disorder: In this prospective study, three main findings were noted: in patients with SCAD, metabolic and epigenetic (miRNA) mediators were associated with TNF-α expression; miR-146a expression levels were negatively correlated with TNF-α levels, irrespective of other metabolic and inflammatory parameters; and miR-146a expression levels were negatively correlated with the severity of coronary artery disease.