SETDB1 and posterior cortical atrophy: For example, increased levels of SETDB1 have been associated with the development and prognosis of bone metastases from PCa, whereas the crucial protein arginine methyltransferase 5 (PRMT5) oncogene has been shown to inactivate several tumor suppressors via arginine methylation at H4R3 histone, thus promoting PCa development [207].