Src-family (SFK) and Ack1 non-receptor tyrosine kinases play a significant role in activating AR through direct phosphorylation, causing a response to very low levels of tissue-expressed, so-called intracrine, androgens, thus facilitating pathways that mediate PCa proliferation, anti-apoptosis, and oncogenic aggressiveness [90]. This evidence concerns the gene NTRK1 and posterior cortical atrophy.