The downregulation of miR-29b and miR-130b seems to modulate the extracellular matrix structure via matrix metalloproteinase 2 (MMP2) and, similarly, pathological loss of miR-205, as widely observed in PCa, may favor tumorigenesis by creating discontinuities in the basement membrane [220,221,222]. This evidence concerns the gene MMP2 and posterior cortical atrophy.