Several epigenetic histone modifiers such as lysine methyltransferases (KMT) and demethylases (KDM), SUV39H1 (KMT1A), and SETDB1 (KMT1E) have been shown to control transcriptional gene regulation and to promote cell migration and invasion in PCa [204,205,206]. This evidence concerns the gene SETDB1 and posterior cortical atrophy.