Several epigenetic histone modifiers such as lysine methyltransferases (KMT) and demethylases (KDM), SUV39H1 (KMT1A), and SETDB1 (KMT1E) have been shown to control transcriptional gene regulation and to promote cell migration and invasion in PCa [204,205,206]. Here, SUV39H1 is linked to posterior cortical atrophy.