Kamanli et al. and Said-Nahal et al. found higher frequency of HLA-B*35 in HLA- B*27 negative SpA patients [24,25] and genetic research on ancient human remains showed an association of HLA-B*40, HLA-B*27 and HLA-B*35 alleles in individuals with rheumatic diseases, particular in individuals with SpA [26]. The gene discussed is HLA-B; the disease is rheumatic disorder.