Univariate analyses indicated serum AFP ≥ 200 ng/mL (HR, 1.721; 95% CI, 1.221–2.426; p = 0.002), tumor size ≥ 5 cm (HR, 2.083; 95% CI, 1.469–2.955; p < 0.001), presence of microvascular invasion (HR, 3.231; 95% CI, 2.122–4.696; p < 0.001), advanced TNM stage (III/IV vs. I/II; HR, 3.356; 95% CI, 2.366–4.761; p < 0.001), pathological grade (poor/moderate vs. well; HR, 2.946; 95% CI, 1.719–5.605; p < 0.001), and PAR2 expression (high vs. low; HR, 2.027; 95% CI, 1.29–3.184; p = 0.002) were associated with significantly poorer OS. This evidence concerns the gene F2RL1 and neoplasm.