In addition to Chibby, serum AFP (≥200 ng/mL; p = 0.002), cirrhosis (p < 0.001), vascular invasion (p < 0.001), advanced TNM stage (p < 0.001), and advanced histological grade (p < 0.001) were associated with poorer OS after resection in patients with HCC. This evidence concerns the gene AFP and Cirrhosis.