F2RL1 and neoplasm: In addition to PAR2 expression, serum AFP (≥200 ng/mL; p < 0.001), cirrhosis (p = 0.001), tumor size (≥5 cm; p = 0.001), number of tumors (multiple tumors; p = 0.006), vascular invasion (p < 0.001), advanced TNM stage (p < 0.001), and advanced histological grade (p < 0.001) were associated with recurrence in HCC (Table 3).