Serum AFP ≥ 200 ng/mL (HR, 1.696; 95% CI, 1.196–2.403; p = 0.003), liver cirrhosis (HR, 1.735; 95% CI, 1.221–2.466; p = 0.002), TNM stage (III/IV vs. I/II; HR, 2.061; 95% CI, 1.447–2.934; p < 0.001), and PAR2 expression (high vs. low; HR, 1.779; 95% CI, 1.181–2.681; p = 0.006) were identified as independent risk factors for recurrence in HCC (Table 4). Here, F2RL1 is linked to hepatocellular carcinoma.