IL6 and Alzheimer disease: Like Hericium erinaceus, Coriolus versicolor has also been shown to improve spatial memory in a mouse model of AD by increasing antioxidant activity (superoxide dismutase (SOD) and catalase (CAT)) and inhibition of pro-inflammatory cytokines (IL-1β, interleukin-6 (IL-6) and TNF-α) [25].