TRPV1 and skin neoplasm: To investigate the effect of TRPV1 antagonists on skin tumor formation, Park et al. treated TRPV1 in keratinocytes with competitive antagonists (AMG-9810 and SB-705498) to potentially use TRPV1 as a pharmacological target, but they could not find skin tumor promotion in epidermal keratinocytes treated by the antagonists [29].