SOD2 and colorectal cancer: This can be obtained through adjustment of the levels of enzymes responsible for production or neutralization of ROS and may be connected to miRNA levels; for example, miR-99a and miR-137 which target ROS producers such as NOX are downregulated in adenocarcinoma [55] and prostate cancer [65], respectively and miR-212 which targets SOD2 is decreased in colorectal cancer, causing elevation of SOD2 levels [103].