In line with these preclinical studies, a case study documented the development of immunological tolerance to FVIII in a participant with severe hemophilia A and high-titer FVIII inhibitors following an orthotopic liver transplantation for hepatocellular carcinoma (HCC) in the setting of endogenous FVIII expression from the donor organ [133]. This evidence concerns the gene F8 and hepatocellular carcinoma.