However, GH is able to induce insulin-resistance before the elevation of circulating FFA, suggesting other mechanisms [1,99] such as the induction of SOCS1 and SOCS3, negative regulators of insulin signaling [102], and the modulation of PI3K activity through increased expression of p85alfa, which binds to IRS and inhibits insulin signaling [103,104]. Here, GH1 is linked to Insulin resistance.