Surprisingly, the most common form of tauopathy and, in general, the most common form of dementia, Alzheimer’s disease, appears to actually be a secondary tauopathy, in which tau aggregation is downstream to other pathogenic events and coexist with aggregates made up of Aβ (a sine qua non conditions for AD diagnosis) and other misfolded proteins. This evidence concerns the gene MAPT and tauopathy.