Among 17 genes involved in cancer pathways, five genes, i.e., BCL2, CXCL8, FGF1, MAPK8, and RASSF1A, whose expression was significantly reduced in ATAT1 KO cells, were simultaneously downregulated by ER stress with tunicamycin treatment, and the expression of all of these genes was recovered upon ATAT1 overexpression. This evidence concerns the gene BCL2 and cancer.