In addition, increased microtubule acetylation by α-tubulin N-acetyltransferase 1 (αTAT1) promotes the invasiveness of colon cancer cells via Wnt/β-catenin signaling [16], and microtubule hyperacetylation through sirtuin 2 (SIRT2) inhibition promotes the proliferation of cancer cells and the growth of tumors [17]. Here, SIRT2 is linked to cancer.