Among these, both autosomal recessive and autosomal dominant inheritance patterns were found, including known (AR IRF7 and IFNAR1 deficiencies, and AD TLR3, TRIF, TBK1 and IRF3 deficiencies) and novel (AD UNC93B, IRF7, IFNAR1 and IFNAR2 deficiencies) disorders of these pathways. Here, IRF3 is linked to Alzheimer disease.