IKBKE and central nervous system cancer: Moreover, let-7b-3p is believed to possess a tumor repressing ability in gliomas, its decreased expression being correlated to a poorer prognosis in patients with these lesions via a disturbed suppression of inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE), E2F2, and the oncogenes KRAS, HMGA2 and MYC [124,125,126].