In other domains, more research efforts have been directed toward finding out other treatment alternatives to ease COVID-19 severity in vulnerable patients, especially acute respiratory distress symptoms mainly caused by neutrophil elastase (NE) enzyme, an intracellular enzyme stored in azurophilic granules of polymorphonuclear neutrophils (PMNs) that are a major component of human innate immunity [6,7]. This evidence concerns the gene ELANE and COVID-19.