The APP/PS1 [85] and Tg2576 [86] mice, as well as selective dopaminergic receptors, cause a blockade in the pre-limbic region of the prefrontal cortex [86] or STOP-null mice modeling schizophrenia [87], also show a reduction of spontaneous alternation, suggesting its relation to frontal hypofunctionality. Here, MAP6 is linked to schizophrenia.